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Short and long-term outcomes of endoscopic balloon dilatation for Crohn’s disease strictures
Katsuya Endo,Seiichi Takahashi,Hisashi Shiga,Yoichi Kakuta
World Journal of Gastroenterology , 2013, DOI: 10.3748/wjg.v19.i1.86
Abstract: AIM: To investigate the short and long-term outcomes of endoscopic balloon dilatation (EBD) for Crohn’s disease (CD) strictures. METHODS: Between January 1995 and December 2011, 47 EBD procedures were performed in 30 patients (8 females and 22 males) with CD. All patients had strictures through which an endoscope could not pass, and symptoms of these strictures included abdominal pain, abdominal fullness, nausea, and/or vomiting. The 47 strictures included 17 anastomotic and 30 de novo strictures. Endoscopy and dilatation were performed under conscious sedation with intravenous diazepam or flunitrazepam. The dilatations were all performed using through-the-scope balloons with diameters from 8 mm to 20 mm on inflation and lengths of 30-80 mm. Each dilatation session consisted of two to four, 3-min multistep inflations of the balloon, repeated at intervals of 1 wk until adequate dilatation (up to 15-20 mm in diameter) was achieved. The follow-up data were collected from medical records and analyzed retrospectively. Primary success was defined as passage of the scope through the stricture after EBD. Long-term outcomes were analyzed focusing on intervention-free survival and surgery-free survival demonstrated by the Kaplan-Meier method. (Intervention-free meant cases in which neither endoscopic balloon re-dilatation nor surgery was needed after the first dilatation during the observation period). The log rank test was used to evaluate the difference in long-term outcomes between anastomotic and de novo stricture cases. RESULTS: Primary success was achieved in 44 of the 47 strictures (93.6%). Balloon dilatations failed in 3 cases (6.4%). In 1 case, EBD was a technical failure because the guide-wire could not be passed through the stricture which showed severe adhesion and was a flexural lesion of the intestine. In 2 cases, unexpected perforations occurred immediately after balloon dilatation. Of the 47 treatments, complications occurred in 5 (10.6%). All 5 patients had de novo strictures. One suffered bleeding, two high fever and there were colorectal perforations. One of the patients with a colorectal perforation was treated surgically, the other was managed conservatively. These 2 cases correspond to the two aforementioned EBD failures. Long-term outcomes were evaluated for the 44 successfully-treated strictures after a median follow-up of 26 mo (range, 2-172 mo). During the observation period, re-strictures after EBDs occurred in 26 cases (60.5%). Fourteen of these 26 re-stricture cases underwent EBD again, but in two EBD failed and surgery was ultimately
Two Cases of Diffuse Duodenitis Associated with Ulcerative Colitis
Katsuya Endo,Masatake Kuroha,Hisashi Shiga,Yoichi Kakuta,Seiichi Takahashi,Yoshitaka Kinouchi,Tooru Shimosegawa
Case Reports in Gastrointestinal Medicine , 2012, DOI: 10.1155/2012/396521
Abstract: The upper gastrointestinal tract is not generally considered a target organ in ulcerative colitis (UC). However, several cases showing upper gastrointestinal involvement in UC have been reported. In this report, we present 2 rare cases of diffuse duodenitis accompanying pancolonic UC. Case patient 1 was a 44-year-old man who developed diffuse duodenitis shortly after colectomy and was successfully treated with mesalazine. Case patient 2 was a 25-year-old woman who developed diffuse duodenitis under a steroid-free condition and was successfully treated with prednisolone. The 2 patients had Helicobacter pylori-negative duodenitis that resembled colonic lesions of UC in both the endoscopic and histological findings. No evidence of Crohn’s disease was found in these cases. We diagnosed both cases as typical UC-associated diffuse duodenitis. The occurrence of gastrointestinal involvement in UC has been attracting attention because such lesions could potentially open a new window for studying the etiology and pathogenesis of UC. Further studies involving a large number of patients are needed to clarify whether the upper gastrointestinal tract is a target organ in UC.
Two Cases of Diffuse Duodenitis Associated with Ulcerative Colitis
Katsuya Endo,Masatake Kuroha,Hisashi Shiga,Yoichi Kakuta,Seiichi Takahashi,Yoshitaka Kinouchi,Tooru Shimosegawa
Case Reports in Gastrointestinal Medicine , 2012, DOI: 10.1155/2012/396521
Abstract: The upper gastrointestinal tract is not generally considered a target organ in ulcerative colitis (UC). However, several cases showing upper gastrointestinal involvement in UC have been reported. In this report, we present 2 rare cases of diffuse duodenitis accompanying pancolonic UC. Case patient 1 was a 44-year-old man who developed diffuse duodenitis shortly after colectomy and was successfully treated with mesalazine. Case patient 2 was a 25-year-old woman who developed diffuse duodenitis under a steroid-free condition and was successfully treated with prednisolone. The 2 patients had Helicobacter pylori-negative duodenitis that resembled colonic lesions of UC in both the endoscopic and histological findings. No evidence of Crohn’s disease was found in these cases. We diagnosed both cases as typical UC-associated diffuse duodenitis. The occurrence of gastrointestinal involvement in UC has been attracting attention because such lesions could potentially open a new window for studying the etiology and pathogenesis of UC. Further studies involving a large number of patients are needed to clarify whether the upper gastrointestinal tract is a target organ in UC. 1. Introduction Ulcerative colitis (UC) is a chronic inflammatory disease of the colon that has an unknown etiology. Although UC is known to have various extracolonic manifestations, the upper gastrointestinal tract is not generally considered a target organ. However, several case reports describing upper gastrointestinal involvement in UC have been published [1–4]. These reports described gastritis or diffuse duodenitis that resembled colonic lesions of UC in both the endoscopic and pathological findings. Recently, some case series and case-control studies reported that gastroduodenal involvement in UC may be more frequent than previously estimated [5–8]. The occurrence of gastrointestinal involvement in UC has been attracting attention because such lesions could potentially open a new window for studying the etiology and pathogenesis of UC. In this report, we describe our experience of 2 rare cases of diffuse duodenitis associated with UC. 2. Case Presentation 2.1. Case 1 A 44-year-old man with a 4-year history of pancolonic UC underwent laparoscopy-assisted proctocolectomy because his disease was severe and steroid resistant. No evidence of Crohn’s disease was found at the time of surgery, and the gross and microscopic features of the colectomy specimen were those of typical pancolonic UC. On the 10th day after the operation, he complained of epigastralgia and tarry stool. Endoscopy of the
MicroRNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6
Atsushi Masamune,Hisashi Shiga,Katsuya Endo,Masatake Kuroha,Seiichi Takahashi,Shin Hamada,Tomoya Kimura,Tooru Shimosegawa,Toshihiro Tadano,Yoichi Kakuta,Yoko Kawakami,Yoshitaka Kinouchi,Yosuke Shimodaira
- , 2016, DOI: 10.4251/wjgo.v8.i7.532
Abstract:
Allele-specific DNA methylation of disease susceptibility genes in Japanese patients with inflammatory bowel disease
Hirofumi Chiba,Hisashi Shiga,Katsuya Endo,Kazuhiro Watanabe,Kenichi Negoro,Masao Nagasaki,Masatake Kuroha,Michiaki Unno,Motoyuki Onodera,Munenori Nagao,Rintaro Moroi,Takeo Naito,Tomoya Kimura,Tooru Shimosegawa,Yoichi Kakuta,Yoshitaka Kinouchi,Yoshitake Kanazawa,Yosuke Kawai
- , 2018, DOI: 10.1371/journal.pone.0194036
Abstract:
Locking Local Oscillator Phase to the Atomic Phase via Weak Measurement
Nobuyasu Shiga,Makoto Takeuchi
Physics , 2011, DOI: 10.1088/1367-2630/14/2/023034
Abstract: We propose a new method to reduce the frequency noise of a Local Oscillator (LO) to the level of white phase noise by maintaining (not destroying by projective measurement) the coherence of the ensemble pseudo-spin of atoms over many measurement cycles. This scheme uses weak measurement to monitor the phase in Ramsey method and repeat the cycle without initialization of phase and we call, "atomic phase lock (APL)" in this paper. APL will achieve white phase noise as long as the noise accumulated during dead time and the decoherence are smaller than the measurement noise. A numerical simulation confirms that with APL, Allan deviation is averaged down at a maximum rate that is proportional to the inverse of total measurement time, tau^-1. In contrast, the current atomic clocks that use projection measurement suppress the noise only down to the level of white frequency, in which case Allan deviation scales as tau^-1/2. Faraday rotation is one of the possible ways to realize weak measurement for APL. We evaluate the strength of Faraday rotation with 171Yb+ ions trapped in a linear rf-trap and discuss the performance of APL. The main source of the decoherence is a spontaneous emission induced by the probe beam for Faraday rotation measurement. One can repeat the Faraday rotation measurement until the decoherence become comparable to the SNR of measurement. We estimate this number of cycles to be ~100 cycles for a realistic experimental parameter.
To the Hilbert class field from the hypergeometric modular function
Atsuhira Nagano,Hironori Shiga
Mathematics , 2015,
Abstract: In this article we make an explicit approach to the higher degree case of the problem: " For a given $CM$ field $M$, construct its maximal abelian extension $C(M)$ (i.e. the Hilbert class field) by the adjunction of special values of certain modular functions" in a restricted case. We make our argument based on Shimura's main result on the complex multiplication theory of his article in 1967. His main result is constructed for a quaternion algebra $B$ over a totally real number field $F$. We determine the modular function which gives the canonical model for the case $B$ is coming from an arithmetic triangle group. That is our main theorem. And we make an explicit case-study for $B$ corresponding to the triangle group $\Delta (3,3,5)$. The corresponding canonical model appears as a restriction of the Appell's hypergeometric modular function on a 2-dimensional hyperball to a hyperplane section. That is a modular function for the family of the Koike pentagonal curves $w^5=z(z-1)(z-\lambda_1)(z-\lambda_2)$ with two parameters $\lambda_1,\lambda_2$. We use the result of K. Koike in 2003 to get an theta representation of the canonical model function. By using this expression, we show several examples of the Hilbert class fields of the $CM$ fields those are embedded in the above $B$.
Projective structures with discrete holonomy representations
Hiroshige Shiga,Harumi Tanigawa
Mathematics , 1995,
Abstract: Let $K(X)$ denote the set of projective structures on a compact Riemann surface $X$ whose holonomy representations are discrete. We will show that each component of the interior of $K(X)$ is holomorphically equivalent to a complex submanifold of the product of Teichm\"uller spaces and the holonomy representation of every projective structure in the interior of $K(X)$ is a quasifuchsian group.
Statistical Survey of Deaths from Nonmelanoma Skin Cancer in Japan during 54 Years
Hisashi Ohtsuka
Journal of Skin Cancer , 2011, DOI: 10.1155/2011/293926
Abstract: The author analyzed the annual trends in the number of deaths from nonmelanoma skin cancer (NMSC) from 1955 to 2008 in Japan on the basis of the data from the Vital Statistics of Japan. The general trends in the number of deaths from NMSC were downward between 1979 to 1994, but upward after 1995. The general trends in age-standardized death rates were roughly downward, although the death rates plateaued after 1995. The recent annual increased ratio of deaths from NMSC was 3.8% (95% confidence interval: 2.7?~?4.9%). The number and proportion of deaths from NMSC among the elderly were increasing in Japan. For females, more than 50% of the deaths occurred recently at or after 85?years of age, whereas, for males, this proportion was at or after 75?years of age, nearly reaching at or after 80?years of age. 1. Introduction The incidence of nonmelanoma skin cancer (NMSC) has been increasing during the past half century in many countries [1–6]. Authors performed the analysis of changing trends in the number of deaths from NMSC in Japan from 1955 to 2000 [7]. This time, the author expanded the period of survey to 2008 and revised the analysis, using the new WHO standard population which is effective for the period 2000–2025 [8]. 2. Material and Methods The annual trends in the number of deaths from NMSC in Japan from 1955 to 2008, those in age-standardized death rates, those in 3-year moving average, those by 5-year age group, those by sex and age group, and those in the proportion of deaths by sex and age group were investigated on the basis of the data from the Vital Statistics of Japan, Statistics and Information Department, Minister's Secretariat, Ministry of Health, Labor and Welfare. The corresponding revisions of the International Classification of Diseases (ICD) and codes were ICD-6 code 191 in 1955–1957, ICD-7 code 191 in 1958–1967, ICD-8 code 173 in 1968–1978, ICD-9 code 173 in 1979–1994, and ICD-10 code C44 in 1995–2008, respectively. The author, however, treated the results continuously from 1955 to 1967, because there was no difference between ICD-6 and ICD-7 concerning NMSC. The author treated the remaining revisions as discontinuous, because there was a minor difference between ICD-6/-7, ICD-8, ICD-9, and ICD-10. The author judged that it would be possible to obtain the general annual trends in the number of deaths from NMSC in Japan for 54 years, although, strictly speaking, there were four times minor changes of ICD classifications concerning NMSC between these periods. The death rates were adjusted every year using the new WHO world standard
Production of gold-198 grains
Hisashi Kato
Gold Bulletin , 1978, DOI: 10.1007/BF03215093
Abstract:
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